I've ridden a lefty a couple times, and apart from the visuals, it didn't really feel unusual. I more or less didn't notice that I was on a lefty.

Here's an article that looks at it a bit more in depth: https://factoryjackson.com/2016/02/18/cannondale-lefty-the-s...

I haven't tried a 2WD, but everything I've read suggests that the added weight and friction delivers pretty limited utility, at least in non-electric versions.