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This is actually a really fascinating topic:

http://en.wikipedia.org/wiki/Endocannabinoid_system

Endocannabinoids are fat-soluble chemicals used for local signaling, most notably retrograde signaling among neurons: they can send signals backwards. They're hydrophobic, diffusing well through cell membranes but not traveling well in water. This makes them useful for sending very short-distance signals.



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