Ableton or Lightroom both have some level of support under Wine but it depends on the version you need. But both also have alternatives and IME killer-apps tend to become a lot less important once users have sufficient other motivations. Nothing is really irreplaceable.
I would love to replace Lightroom, but unfortunately the alternatives just aren't as good.
There are good alternatives to Ableton, but once you get to know a DAW it is hard to switch. And running a DAW with an ecosystem of 3rd party VST plugins and low level access to audio hardware on Wine sounds like a recipe for a bad time, but I confess I haven't tried it.
So, yes, these things are possible, but it is still easier to just use Windows.
