I haven’t the tried Hyprland, but I use i3, which I assume it should be similar. I do this sort of thing quite often when presenting on zoom at work. Suppose I want to present only the top-left section of my screen, then I split vertically first and the left side I split horizontally. This other 2 zones I use to put other supporting windows and to search stuff out of screen. When I need to present more apps, i3 also allow you to stack windows in a specific zone. It’s quite easy to switch between all the windows and have full control of the layout.